ADVANTIX SPOT-ON 4 KG - ALSO AVAILABLE IN THE CATALOG IN PACK OF 6

PIPETTES Pharmacotherapeutic category Ectoparasiticides. Pyrethrins and pyrethroids.
Permethrin, associations.

Active ingredients: Imidacloprid 100 mg/ml; permethrin 500 mg/ml.
Excipients Butylhydroxytoluene (E321): 1.0 mg/ml; n-methylpyrrolidone;
mile 812; citric acid (E330).

Indications: For the treatment and prevention of infestations
fleas (C.canis, C.felis) and for the treatment of louse (Trichodectes canis)
in dogs. Fleas on dogs are killed within a day of treatment. A
treatment prevents further flea infestation for four weeks. The
product can be used as part of a treatment strategy for
flea allergy dermatitis (FAD). The product has persistent activity
acaricide and repellent against tick infestations (Rhipicephalus
sanguineus and Ixodes ricinus for four weeks, and Dermacentor reticulatus for
three weeks). It is possible that ticks already present on the dog will not come
killed within two days after treatment and remain attached and visible.
It is therefore recommended to remove ticks already present on the dog
moment of treatment, in order to prevent them from attaching and consuming a
blood meal. A treatment provides a repellent (anti-feeding) activity
against sandflies (Phlebotomus papatasi for two weeks and Phlebotomus
perniciosus for three weeks), against mosquitoes (Aedes aegypti for two
weeks and culex pipiens for four weeks) and against horse flies
(Stomoxys calcitrans) for four weeks.

Contraindications/secondary effects: In the absence of available data, the
Product should not be used on puppies under the age of 7
weeks or 1.5 kg of weight. Do not use in case of hypersensitivity to the principles
active ingredients or to any of the excipients. Do not use on cats.

Use/route of administration: Topical.

Dosage: The minimum recommended dose is 10 mg of imidacloprid per
kg body weight and 50 mg permethrin per kg body weight. The volume of
product corresponds to 0.4 ml.

To reduce reinfestation due to
appearance of new fleas, it is recommended to treat all animals present
in the domestic environment. The other animals living in the same environment
household must be treated with a suitable product. To contribute
to further reduce the environmental threat, additional use is recommended
of a suitable environmental treatment against adult fleas and their stages
way of development. The product remains effective even if the animal gets wet. Yes
however, you must avoid intense and prolonged exposure to water. In case of
Frequent exposure may reduce the persistence of efficacy. In
in these cases do not repeat the treatment more frequently than once a day
week. If shampooing is required for your dog, it is best to do so first
of the application of the product or at least two weeks later in order to
optimize its effectiveness. In case of lice infestation, it is
a further veterinary visit is recommended 30 days after treatment,
because some animals may require a second treatment. To apply
only on intact skin. Do not apply an excessive amount to any of the points
of solution that can cause a part of the latter to flow along the
dog's hips.

Storage: Do not freeze. After opening the foil pouch,
Store in a dry place at a temperature not exceeding 30 degrees C.

Warnings: It is possible that individual ticks attach or that individual
sandflies or mosquitoes bite. For this reason, if the conditions are
unfavorable conditions, disease transmission cannot be completely ruled out
infectious by these parasites. However, the product provides a
repellent activity (anti-feeding) against ticks, sandflies and
mosquitoes, thus preventing the repelled parasites from taking a blood meal
and thus reducing the risk of transmission of dog-borne diseases
vector (Canine Vector, Borne Disease, CVBD), such as borreliosis,
rickettsiosis, ehrlichiosis, leishmaniasis. You must be careful to avoid that
the contents of the pipette come into contact with your eyes or mouth
treated animals. Care must be taken when administering the product
correctly, in particular, oral intake due to the
licking of the application site by the treated animals or by
of animals in contact with them.

Do not use on cats.

This product is
extremely toxic to cats and could be fatal, due to
peculiar physiology of the cat which is incapable of metabolising certain compounds,
including permethrin. To prevent cats from being accidentally exposed to the product, keep treated dogs away from cats after treatment and
until the application site has dried.

Special precautions for those administering: avoid contact of the product with the skin, eyes or mouth. Wash your hands thoroughly after use. In case of accidental spillage on the skin, wash immediately with soap and water. People with sensitivity
known skin may be particularly sensitive to this product. THE
predominant clinical symptoms which in extremely rare cases may occur
are transient sensory irritations of the skin such as tingling, sensation
of burning or numbness. If the product accidentally ends up in the
eyes, rinse them thoroughly with water. If skin or eye irritation
persists or if the product is accidentally ingested, contact
see a doctor immediately. Treated dogs should not be handled, in
particularly by children, until the application site has dried.
This can for example be ensured by treating the dogs in the evening. Overdose:
No adverse clinical signs were noted in puppies or adult dogs
healthy, exposed to an overdose of 5 times the recommended dose, or
in puppies whose mothers had been treated with an overdose of the product
equal to 3 times.

Waiting time: Not applicable.

Target species: Dogs.

Interactions: None known.

Side effects: On very rare occasions, dogs may
experience transient skin sensitivity (increased local itching,
scratching and rubbing, hair loss and redness at the site of
application) or lethargy which generally resolve spontaneously. In cases
very rare dogs may show behavioral changes (agitation,
restlessness, moaning or rolling movements) gastro-intestinal symptoms
(vomiting, diarrhea, hypersalivation, decreased appetite) and signs
neurological disorders such as staggering and twitching in dogs sensitive to
substance permethrin. These signs are usually transient and resolve
spontaneously. Poisoning in dogs following intake is unlikely
involuntary oral, although this can occur in very rare cases. In this
In this case, neurological signs such as tremors and lethargy may occur. The
treatment must be symptomatic. There are no known specific antidotes.

Pregnancy and breastfeeding: Can be used during pregnancy and
breastfeeding.